Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy
نویسندگان
چکیده
منابع مشابه
Levetiracetam-loaded biodegradable polymer implants in the tetanus toxin model of temporal lobe epilepsy in rats.
Approximately one-third of people with epilepsy receive insufficient benefit from currently available anticonvulsant medication, and some evidence suggests that this may be due to a lack of effective penetration into brain parenchyma. The current study investigated the ability of biodegradable polymer implants loaded with levetiracetam to ameliorate seizures following implantation above the mot...
متن کاملAsynchronous Distributed Multielectrode Microstimulation Reduces Seizures in the Dorsal Tetanus Toxin Model of Temporal Lobe Epilepsy.
BACKGROUND Electrical brain stimulation has shown promise for reducing seizures in drug-resistant epilepsy, but the electrical stimulation parameter space remains largely unexplored. New stimulation parameters, electrode types, and stimulation targets may be more effective in controlling seizures compared to currently available options. HYPOTHESIS We hypothesized that a novel electrical stimu...
متن کاملStructural substrates for resting network disruption in temporal lobe epilepsy.
Magnetic resonance imaging methods that measure interregional brain signalling at rest have been advanced as powerful tools to probe organizational properties of functional networks. In drug-resistant temporal lobe epilepsy, resting functional magnetic resonance imaging studies have primarily employed region of interest approaches that preclude a comprehensive evaluation of large-scale function...
متن کاملComparison of temporal lobe epilepsy with hippocampal sclerosis and temporal lobe epilepsies due to other etiologies
Background: This study compares the clinical characteristics of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) with those who have temporal lobe epilepsy (TLE) due to other etiologies. Methods : In this retrospective study all patients with a clinical diagnosis of TLE were recruited in a referral outpatient epilepsy clinic at Shiraz University of Medical Sc...
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ژورنال
عنوان ژورنال: Brain Structure and Function
سال: 2014
ISSN: 1863-2653,1863-2661
DOI: 10.1007/s00429-013-0697-1